相关实验视频

Updated: Jun 25, 2025

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles

Published on: May 14, 2021

使用纳米载体重编程瘤相关的巨细胞:阻止癌症进展的新视角

Alyona B Kuznetsova¹, Ekaterina P Kolesova¹, Alessandro Parodi¹

¹Scientific Center for Translation Medicine, Sirius University of Science and Technology, 354340 Sochi, Russia.

|May 25, 2024

概括

与瘤相关的巨细胞 (TAMs) 促进癌症的生长. 使用纳米技术将这些类似M2的TAM重新编程为使用纳米技术的抗瘤M1表型,为抑制瘤进展和提高治疗疗效提供了一个有希望的策略.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
纳米技术纳米技术

背景情况:

癌症是一个全球性的健康挑战,瘤微环境 (TME) 对瘤进展至关重要.
与瘤相关的巨细胞 (TAMs),特别是M2类表型,通过促进血管生成,血管透性,化学抵抗和转移,创造了一个支持瘤的环境.

研究的目的:

审查TME中的TAM两极分化及其病理作用.
探索纳米技术用于TAM重编程和耗尽作为辅助癌症治疗.

主要方法:

综合了TME因素影响的TAM两极分化的当前数据.
突出了TAMs在癌症进展中的有害影响.
审查了为TAM调制设计的现有纳米技术.

主要成果:

类似M2的TAMs对瘤生长,血管新生和转移有显著的贡献.
将TAM重新编程为M1表型显示出抗瘤效应的潜力.
纳米技术为TAM重编程和减少不良事件提供了有针对性的交付.

结论:

针对TAMs是新型癌症治疗的可行策略.
基于纳米技术的方法有望实现有效的TAM重编程和耗尽.
对TAM调制纳米医学的进一步研究是有必要的,以改善癌症治疗结果.

关键词:

在M2巨细胞中.抗化学疗法耐药性抗化学疗法耐药性巨细胞再极化发生.纳米疗法是一种纳米疗法.与瘤相关的巨细胞.

更多相关视频

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...