甜味剂对PVP K30-A溶液具有塑化作用,用于固定剂量无形黄素-素固体分散的热挤出

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PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

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Kamil Wdowiak¹, Lidia Tajber², Andrzej Miklaszewski³

¹Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, 3 Rokietnicka St., 60-806 Poznan, Poland.

Pharmaceutics

|May 25, 2024

概括

这项研究开发了使用红醇作为可塑剂的黄素和hesperetin的无形固体分散. 这种配方显著改善了药物的溶解性和溶解性,提供了潜在的神经保护益处.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
药物运输药物运输药物运输

背景情况:

黄素和hesperetin显示出潜在的神经保护活性.
这些化合物的低溶解性限制了它们的治疗疗效.
开发先进配方对于提高生物可用性至关重要.

研究的目的:

为了开发固剂无形固体分散的黄素和hesperetin.
为了克服这些活性化合物的不良溶解性和溶解限制.
评估塑化剂对无形固体分散制剂的影响.

主要方法:

热挤出用于准备无形固体分散.
甜味剂 (乙醇,醇,醇) 被研究为PVP K30的增塑剂.
粉末X射线衍射,热分析和红外光谱学被用于表征.
进行了稳定性研究和药物参数 (溶解,可溶性,透性) 的评估.

主要成果:

红醇被确定为最佳的塑化剂,降低PVP K30.0的玻璃过渡温度.
库尔库和素的无形固体分散物已成功制备并通过表征技术得到证实.
无形状态保持稳定至少6个月.
优化的配方 (15%的活性化合物含有红醇) 在溶解率,溶解度和体外透性方面显著改善.

结论:

固定的剂量无形固体分散的黄素和hesperetin可以有效地准备使用热挤出与红醇作为可塑剂.
这种方法成功地提高了活性化合物的可溶性和溶解性.
开发的配方有望改善神经保护的治疗结果.

关键词:

无形固体分散的分散.库尔库明是一种黄素.没有希望,没有希望.热挤出方式塑化剂塑化剂塑化剂聚维尼尔皮罗利多的使用.甜味剂甜味剂甜味剂甜味剂

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