改善水溶性较差的非类固醇抗炎药物通过皮肤传递的策略
Alexandra Balmanno1, James R Falconer2, Halley G Ravuri3
1School of Veterinary Science, The University of Queensland, Gatton Campus, Gatton, QLD 4343, Australia.
Pharmaceutics
|May 25, 2024
概括
通过皮肤的非类固醇抗炎药物 (NSAIDs) 与口服药物相比具有优势. 像纳米配方和微乳液这样的策略可以提高溶解度和皮肤透度,以改善药物输送.
科学领域:
- 制药科学 制药科学
- 皮肤病学 皮肤病学
- 药物输送系统 药物输送系统
背景情况:
- 口服非类固醇抗炎药物 (NSAIDs) 提出了挑战,包括胃肠道问题和合规性.
- 新型NSAIDs的溶解性差,阻碍了局部配方和系统治疗的有效皮肤透.
研究的目的:
- 审查提高难溶性NSAIDs可溶性和通过皮肤透的策略.
- 探索先进的配方技术,以改善局部NSAID的输送.
主要方法:
- 关于NSAID可溶性增强技术的文献综述.
- 分析修改皮肤屏障功能的方法,以改善透.
- 对纳米尺寸配方和微乳液系统的评估.
主要成果:
- 有各种策略可以改善NSAID的溶解性和皮肤透.
- 先进的配方,包括纳米尺寸的系统,显示了希望.
- 微乳液被确定为一种具有成本效益和成功的技术,用于输送水溶性较差的NSAID.
结论:
- 通过皮肤输送的NSAID可以减轻口服的缺点.
- 增强的溶解性和透性是成功通过皮肤的NSAID配方的关键.
- 微乳液提供了一个可行的解决方案,可以通过皮肤传递溶解不良的NSAID.
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