喷嘴收缩消除对中后轮区域喷雾分布的影响:一项比较研究
Amr Seifelnasr1, Xiuhua Si2, Jinxiang Xi1
1Department of Biomedical Engineering, University of Massachusetts, Lowell, MA 01854, USA.
Pharmaceutics
|May 25, 2024
概括
一种新的鼻喷设计消除了喷嘴的收缩,改善了喷雾的深入到鼻腔的输送. 这种新设备可以提高特定区域的剂量,但可能会增加喉药物损失.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
背景情况:
- 标准的多剂量鼻喷雾患有喷嘴收缩,减少插入深度,影响药物沉积和可变性.
- 这种撤回可能会导致药物浪费增加和剂量不一致,影响治疗疗效.
研究的目的:
- 为了比较新设计的鼻喷的性能,它消除了喷嘴收缩,与传统的相比.
- 为了评估两种设备之间的喷雾生成,羽毛特性和鼻腔剂量分布的差异.
主要方法:
- 使用激光衍射分析了喷雾液滴大小分布.
- 羽毛发育被高清视频录制捕捉到.
- 鼻子剂量测量在不同的呼吸条件下使用光追踪器对透明的鼻腔造进行了评估.
主要成果:
- 两种设备都显示出类似的滴滴大小分布,但新的产生了更窄的羽毛角.
- 经过修改的设备显示了更深的鼻穿透,主要是在中上半导体.
- 在中上轮区域观察到剂量增加, pharynx 药物损失增加.
结论:
- 重新设计的鼻喷有效地消除了喷嘴的收缩,允许喷更深入地透.
- 虽然改进了目标鼻腔区域的沉积,但新的设计需要进一步优化,以最大限度地减少喉药物损失.
相关概念视频
01:29Suctioning the Nasopharyngeal Airway
382
Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required
Equipment Required
382
01:27Open Angle Glaucoma: Treatment
430
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
430