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亚酸和贝他因基础的治疗深度修养系统的配方,用于增强亚酸的通过皮肤输送
Ji-Eun Song1, Seung-Hyun Jun1, Joo-Yeon Ryoo1
1R&D Center, LG Household and Health Care (LG H&H), 70, Magokjungang 10-ro, Gangseo-gu, Seoul 07795, Republic of Korea.
Pharmaceutics
|May 25, 2024
概括
研究人员开发了一种新的治疗性深层体系统 (THEDES),以增强L-酸 (AA) 的稳定性和皮肤透性,用于局部应用. 这一突破改善了抗氧化剂的输送,减少了衰老的迹象,并促进了皮肤色调.
科学领域:
- 制药科学 制药科学
- 皮肤病学 皮肤病学
- 材料科学 材料科学 材料科学
背景情况:
- 酸 (AA) 是一种有价值的局部抗氧化剂,但其稳定性和皮肤透性不佳.
- 由于其固有的不稳定性,现有的配方难以有效地提供AA.
- 开发稳定和透的AA配方对于制药和化品应用至关重要.
研究的目的:
- 创建一种新的治疗性深层体系统 (THEDES),以提高L-甲酸 (AA) 溶解度和通过皮肤传递.
- 通过与贝他因 (Bet) 转化为THEDES来增强AA的稳定性和皮肤透性.
- 为了评估基于AA的THEDES在人类临床研究中对抗衰老作用的疗效.
主要方法:
- 使用显微镜和热分析,制备和描述L-亚斯科布酸和基于贝他因的THEDES.
- 对THEDES在各种多聚醇中的可溶性评估.
- 使用猪皮的体外皮肤透研究.
- 在人体体内进行人体研究,以评估抗衰老效果和皮肤色调改善.
主要成果:
- 基于AA的THEDES表现出高溶解度 (约. 40%) 在常见的聚合物中.
- 与单独的AA或物理混合物相比,THEDES显著增强了AA的皮肤传递.
- 在体内研究表明,含有THEDES的血清减少了衰老标志物,改善了皮肤色调.
- 泰德斯的方法成功地扩展到葡萄糖.
结论:
- 基于AA和Bet的THEDES代表了一个有前途的新型L-甲酸通过皮肤输送系统.
- 泰德斯战略有效地克服了AA的稳定性和透性挑战.
- 这种方法有可能开发先进的局部抗氧化剂配方.
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