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在中国成年人中循环25-基维生素D和代谢综合征之间的关系:一项大型全国纵向研究

Mi Shu^1,2, Yue Xi¹, Jie Wu²

¹Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.

|May 25, 2024

概括

较高的维生素D水平 (25-氧维生素D) 与较低的代谢综合征 (MetS) 和其成分风险有关. 这表明维生素D可能在代谢健康中发挥预防作用.

科学领域:

内分泌学在内分泌学.
营养科学营养科学
公共卫生公共卫生

背景情况:

代谢综合征 (MetS) 是一组疾病,增加患心脏病,中风和2型糖尿病的风险.
循环中的25-氧维生素D (25[OH]D) 是维生素D状态的关键指标.
维生素D水平与MetS风险之间的关系需要在不同人群中进一步调查.

研究的目的:

调查血清25-氧维生素D (25[OH]D) 水平与发展代谢综合征 (MetS) 的风险之间的关联.
为了检查25[OH]D和MetS的个别成分之间的关系,包括腹部肥胖,高甘油三,高甘油三,高甘油三,低HDL胆固醇和高血压.

主要方法:

一项针对23810名中国成年人的全国性队列研究,每年进行健康评估.
随着时间的推移,血清25 ((OH) D水平和MetS状态被评估.
混合混合效应和考克斯回归模型用于横截面和纵向分析.

主要成果:

在具有较高血清25(OH) D水平的个体中,在个人之间 (OR 0.43) 和个人内部 (OR 0.60) 的比较中,观察到MetS的几率明显较低 (四分位数4比1).
较高的25~OH) D水平与腹部肥胖,高甘油三和低HDL胆固醇的风险降低有关.
纵向分析显示,在25~OH) D的最高四分位数中,MetS,高甘油三,腹部肥胖和低HDL胆固醇的危险比率下降.

结论:

血清25(OH) D度的降低与MetS及其组件的风险增加有显著的关联.
循环维生素D可能在代谢障碍中起到预防作用.
维持足够的维生素D水平可能是代谢健康管理的潜在策略.

关键词:

中国成年人成年人中国成年人代谢健康的代谢健康代谢综合征代谢综合征血清中的25-基维生素D 维生素D缺乏症维生素D缺乏症

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