地中海饮食,黄素和白醇对轻度至中度活性性结肠炎的影响:多中心随机临床试验
Özge Erol Doğan1,2, Kezban Esen Karaca Çelik3, Murat Baş3
1Department of Nutrition and Dietetics, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey.
Nutrients
|May 25, 2024
概括
地中海饮食 (MD),有或没有黄素或白醇,有效地降低了性结肠炎 (UC) 患者的疾病活性和炎症. 它还改善了他们的生活质量,显示MDMD.
科学领域:
- 胃肠病学和营养科学 胃肠病学和营养科学
- 临床试验研究 临床试验研究
- 炎症性肠病 (IBD) 管理管理
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病.
- 探索饮食干预措施来管理UC.
- 地中海饮食 (MD) 显示出潜在的抗炎性质.
研究的目的:
- 评估地中海饮食 (MD) 结合黄素或白醇对UC的影响.
- 评估UC患者疾病活动,炎症标志物和生活质量的变化.
- 为了比较单独的MD与MD与补充剂的疗效.
主要方法:
- 未来的,多中心,三臂随机对照试验.
- 在8周的干预期间,使用了MD,MD+curcumin (1600 mg/天),或MD+resveratrol (500 mg/天).
- 评估疾病活动 (Truelove-Witts),生活质量 (SF-36,IBDQ) 和坚持 (MEDAS).
主要成果:
- 所有干预措施都显著降低了UC疾病活性和炎症 (p <0.05).
- 在所有群体中,生活质量都有所改善.
- 两组之间没有显著差异,除了SF-36疼痛和MEDAS分数.
结论:
- 地中海饮食是对轻度至中度活跃性性结肠炎的有效和安全干预措施.
- 在这项试验中,黄素和白醇补充剂没有显示出与单独的MD相比的额外显著益处.
- 值得注意的发现是MD的坚持和疼痛减轻.
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