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富科伊丹通过促进线粒体生物发生和维持肠道微生物群平衡来改善D-银河糖诱导的认知功能障碍

Yan Xu¹, Meilan Xue², Jing Li¹

¹School of Public Health, Qingdao University, Qingdao 266071, China.

|May 25, 2024

概括

富科伊丹有效地通过减少氧化应激和炎症来对抗与年龄相关的认知障碍. 这种天然化合物还可以增强线粒体功能,促进健康的肠道微生物群,提供神经保护.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
生物化学生物化学

背景情况:

与年龄相关的认知障碍越来越令人担忧.
D-银糖 (D-gal) 用于诱导动物模型中的认知功能障碍.
富科伊丹是一种多糖,具有潜在的治疗益处.

研究的目的:

在大鼠中调查富科伊丹对D-gal诱导的认知功能障碍的保护作用.
阐明福科丹神经保护作用的潜在机制.

主要方法:

斯普雷格·道利 (Sprague Dawley) 鼠被给予D-银糖和不同剂量的富可伊丹,持续了8周.
评估了认知功能,海马体组织病理学,氧化应激标志物,炎症水平和线粒体功能.
分析了包括PGC-1α/NRF1/TFAM和APN/AMPK/SIRT1在内的关键分子通路.
评估了肠道菌群的组成.

主要成果:

富科伊丹显著改善了暴露于D-gal的老鼠的认知障碍.
hippocampus 中的组织病理变化被富可伊丹治疗逆转.
富科伊丹减少了氧化应激,炎症,并改善了线粒体功能障碍.
富科伊丹通过与APN/AMPK/SIRT1.1.相关的PGC-1α/NRF1/TFAM通路促进了线粒体生物发生.
神经保护与改善肠道菌群的稳态相关,包括增加的Bacteroidota,Muribaculaceae和Akkermansia,以及减少的Firmicutes.

结论:

富科伊丹在改善D-gal诱导的认知障碍和相关的神经病理变化方面表现出显著的疗效.
富科伊丹通过减轻氧化应激,减少炎症和通过特定的分子通路增强线粒体功能来发挥其神经保护作用.
维持肠道菌群的稳态似乎是福科丹认知益处的关键机制.
富科伊丹是针对与年龄相关的认知衰退的干预措施的有希望的天然成分.

关键词:

D-银糖是什么? D-银糖是什么?认知障碍是一种认知障碍.这就是Fucoidan.我们的肠道微生物组.线粒体生物发生是线粒体生物发生.

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