暴露于酒精和疾病的关联:孟德尔的随机化和对每周饮酒量和问题饮酒的元分析
Mengyao Li1,2, Xuying Zhang1,2, Kailei Chen1,2
1Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention, China Medical University, Ministry of Education, Shenyang 110122, China.
Nutrients
|May 25, 2024
概括
这项研究使用了门德尔的随机化来调查酒精消费和健康风险. 对酒精使用的遗传倾向与帕金森症下降有因果关系.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 酒精消费是全球疾病负担的主要原因之一.
- 观察性研究表明,酒精与各种疾病之间存在联系,但因果关系的证据往往有限.
- 门德尔随机化 (MR) 提供了一个强大的工具,可以从遗传关联中推断因果关系.
研究的目的:
- 综合评估与饮酒模式相关的因果健康风险.
- 整合现有MR研究的发现,并对酒精暴露进行新型MR分析.
- 检查一般饮酒和问题性饮酒对疾病结局的影响.
主要方法:
- 对已发表的关于酒精暴露的门德尔随机化 (MR) 研究进行了系统的搜索.
- 使用两组遗传仪器变量进行了 de novo MR 分析:酒精消耗和问题性酒精使用.
- 利用FinnGen财团R9发布的总结统计数据进行了新的分析,涵盖了76个不同的主要结果.
主要成果:
- 对饮酒的遗传倾向与降低患帕金森病,前列腺增生和类风湿关节炎的风险存在因果关系.
- 饮酒也与慢性胰腺炎,结直肠癌和头癌的风险增加有关.
- 对问题性酒精使用的遗传倾向与酒精性肝病,肝硬化,胰腺炎和肺炎的风险增加密切相关.
结论:
- 饮酒和问题性饮酒与广泛的疾病有因果关系.
- 酒精使用对疾病的主要因果影响似乎是通过增加风险.
- MR提供了强有力的证据,证明酒精消费模式对健康的有害影响.
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