在新辅助化疗和放射治疗后病理完整反应的直肠癌患者手术样本的总体形态特征:一个横截面研究
Amir Reza Fazeli1,2, Kiana Tadbir Vajargah1,2, Mohammad Sadegh Fazeli1,2
1Division of Colorectal Surgery, Department of Surgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
World journal of surgery
|May 25, 2024
概括
大多数获得病理完整反应 (pCR) 的直肠癌患者显示残留严重异常,特别是. 较高的预治疗阶段与这些性发现相关,影响治疗决策.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 手术病理学手术病理学
背景情况:
- 在非辅助性化疗和手术后,10%-30%的直肠癌患者实现了病理完整反应 (pCR).
- 剩余的粘膜异常可能不准确地将患者排除在非手术治疗之外,尽管实现了pCR.
- 在pCR直肠癌患者的总体发现需要详细报告.
研究的目的:
- 报告获得病理完整反应 (pCR) 的直肠癌患者的粗略发现.
- 研究PCR患者治疗前特征与严重异常之间的关联.
主要方法:
- 对130名用新辅助化学放射治疗和手术治疗的直肠腺癌患者的回顾性分析.
- 收录标准:PCR的外科病理报告.
- 收集的数据:人口统计数据,治疗前瘤特征和术后粗大发现 (性病变与非性病变).
主要成果:
- 88.5%的pCR患者表现出严重的异常 (或非性病变).
- 较高的治疗前瘤阶段与性病变相关 (p=0.05).
- 较年轻的患者表现出更深层次参与的趋势 (p=0.013).
结论:
- 大多数获得pCR的直肠癌患者存在严重异常.
- 在pCR患者中,更高的预治疗阶段与严重异常,特别是有显著联系.
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