作为控制Helicobacter pylori相关疾病的辅助剂的黄和黄素:叙事性审查
Lyudmila Boyanova1, José Medeiros2, Daniel Yordanov1
1Department of Medical Microbiology, Medical University of Sofia, 1431 Sofia, Bulgaria.
Letters in applied microbiology
|May 25, 2024
概括
黄是一种黄化合物,通过抑制细菌生长和提高根除率,显示出控制Helicobacter pylori感染的前景. 它还提供抗癌益处,并支持肠道健康,表明其作为治疗辅助的潜力.
科学领域:
- 自然产品 化学 化学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 杆菌感染是一个全球性的健康问题,需要新的治疗策略.
- 目前正在探索非抗生素辅助剂,以改善感染控制和打击抗生素耐药性.
- 黄中的主要生物活性化合物黄,具有多种生物活性.
研究的目的:
- 审查并强调黄素在控制Helicobacter pylori感染方面的益处.
- 探索黄素作为H. pylori根除和胃癌的辅助疗法的潜力.
- 评估黄素对肠道微生物群的安全性和影响.
主要方法:
- 主要自2020年以来,对英语出版物的文献搜索,使用与黄素和H. pylori相关的关键词.
- 对调查黄素对H.pylori的体外和体内影响的研究分析.
- 对临床试验和关于黄素补充剂的安全数据的审查.
主要成果:
- 库尔库证明了剂量和菌株依赖的抑制H. pylori生长,尿酶活性,毒性基因 (cag) 和生物膜形成.
- 黄素表现出抗癌性质,包括诱导亡,抗炎作用和化学敏感性.
- 临床研究表明,黄素补充剂增加了H. pylori根除成功率,当添加到标准的三重疗法时.
- 通过各种先进的输送系统,可以提高黄素的生物可用性.
- 黄素通常是安全的,胃肠道不适是最常见的副作用,并且有利地影响了肠道微生物群,抑制了C. difficile.
结论:
- 黄素显示出作为H. pylori感染治疗中的辅助剂的显著潜力.
- 它的抗癌性质和对肠道微生物群的积极影响进一步支持其治疗价值.
- 需要进一步的研究来优化黄素剂量,抗生素协同作用,以及其在根除方案和预防中的作用.
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