N-乙基二:一个非常长和糟糕的旅程! 一个案例系列
Sandrine Lefeuvre1,2, Camille Richeval3,4, Jeremy Lelong1
1Toxicology and Pharmacokinetics Laboratory, University Hospital, 2 Rue de la Miletrie, Poitiers, 86021, France.
Journal of analytical toxicology
|May 25, 2024
概括
N-乙基德 (NEH) 中毒会导致严重的不良事件和长时间的可检测寿命. 识别NEH代谢物有助于检测消费和了解其毒性影响.
科学领域:
- 法医毒理学 法医毒理学
- 临床化学 临床化学
- 药理学 药理学是指药理学的学科.
背景情况:
- N-乙烯二 (NEH) 是一种新型的加西衍生物,毒动力学和毒动力学数据有限.
- NEH中毒的临床表现没有得到充分的记录.
研究的目的:
- 为了记录N-乙烯 (NEH) 中毒的临床病例.
- 分析生物样本中的NEH度,并识别其代谢物.
- 描述NEH的毒性动力学特征和不良影响.
主要方法:
- 三名患者的案例研究,怀疑N-乙烯 (NEH) 中毒.
- 使用液体染色学-高分辨率质谱法 (LC-HRMS) 和LC-MS-MS分析血和尿液样本.
- 鉴定和量化NEH及其代谢物.
主要成果:
- 在所有血和尿液样本中检测到N-乙烯基 (NEH).
- 定量分析显示,随着时间的推移,NEH度下降,估计消除半衰期为19小时和28小时.
- 确定了四种NEH代谢物:减少的NEH,脱基-NEH,减少的脱基-NEH和基-NEH.
- 患者经历了严重的不良事件,包括焦虑,偏执和意识丧失,其中两个需要输管和通风.
结论:
- 在生物样本中,N-乙烯二 (NEH) 的可检测寿命较长.
- 已识别的代谢物可以帮助法医识别NEH消耗.
- NEH中毒可能导致严重的临床表现和不良事件,需要医疗干预.
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