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芬托胺和维生素B用于晚期早产婴儿的食不耐受:一项随机试验
Yuan-Yuan Lv1, Ning Gao2, Xin He2
1The Infection Control Office, Baoding No.1 Central Hospital, Baoding, China.
Asia Pacific journal of clinical nutrition
|May 25, 2024
概括
芬托胺和B族维生素有效地减少了晚期早产婴儿的胃肠道症状和炎症,这些婴儿有食不耐受. 这种组合疗法改善了治疗结果,而不会增加并发症.
科学领域:
- 新生儿科学 新生儿科学
- 儿科胃肠病学 儿科胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 食不耐受 (FI) 是晚期早产婴儿 (34至<37周妊娠年龄) 的普遍问题.
- 在这个弱势群体中,对FI的有效管理策略至关重要.
研究的目的:
- 评估将托胺与B族维生素结合用于治疗晚期早产婴儿食不耐症的疗效和安全性.
- 研究这种联合治疗对胃肠道症状,炎症标志物和临床结果的影响.
主要方法:
- 一项随机对照试验,涉及118名晚期早产婴儿,被诊断患有FI.
- 婴儿被分配给静脉注射芬托胺和肌肉内注射维生素B或标准护理.
- 测量结果包括胃肠道症状的持续时间,医院出院的时间,炎症标志物水平和并发症率.
主要成果:
- 芬托胺和维生素B组的胃肠道症状持续时间明显较短 (p < 0.01).
- 在治疗组中观察到较低的炎症标志物度和更高的整体有效治疗率 (p < 0.05).
- 两组之间在住院时间,基底水平,体重恢复或并发症发生率方面没有发现显著差异.
结论:
- 联合托胺和B族维生素疗法在缓解胃肠道症状和减少FI晚期早产婴儿的炎症方面表现出有效性.
- 这种治疗方法可以改善食耐受性的关键指标,但不会对并发症发生率产生不利影响.
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