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通过3D打印的基于氧酸盐的模板进行Ca释放和骨质传导之间的相关性

Mohamad N Hassan^1,2, Ahmed M Eltawila^3,4, Samih Mohamed-Ahmed¹

¹Centre for Translational Oral Research (TOR), Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, Årstadveien 19, Bergen 5009, Norway.

ACS applied materials & interfaces

|May 25, 2024

概括

用于骨组织工程的基于酸 (HA) 的模板在低释放率下显示出最佳的骨质导电性. 从HA模板中释放的高阻碍了新的骨形成,无论是体外还是体外.

科学领域:

生物材料科学生物材料科学
组织工程是组织工程.
整形外科的研究研究.

背景情况:

酸 (HA) 是一种用于骨组织工程的骨传导生物陶.
它的骨质导电性有所变化,对于骨再生的最佳 (Ca) 释放水平仍未确定.
HA模仿了骨的矿物成分,增强了组织的整合.

研究的目的:

为了研究基于HA的模板的Ca释放率和骨质导电性之间的相关性.
评估不同度的HA对模板性质和骨再生的影响.
为了比较体外和体外骨质导体性能.

主要方法:

通过10%,30%和50%的HA比率的融挤出3D打印制造HA/多聚乳酸-共三甲烯碳酸 (PLATMC) 复合模板.
评估可打印性和物理性能.
在体外评估使用人类骨髓衍生中酶体干细胞来测量矿化细胞外基质 (ECM) 分泌.
在子形缺陷模型中的体内评估,以量化新的骨形成.

主要成果:

与原始的PLATMC相比,10%的HA (HA10) 模板在体外显示轻度的Ca释放和增强的矿化ECM分泌.
从30%和50%的HA模板 (HA30,HA50) 中释放的高碳酸导致骨质传导减少,并阻碍了ECM分泌.
在体内,PLATMC和HA10显示出优异的新骨形成和直接接触骨质生成,而HA30和HA50显示出远程骨质生成和较少的骨生长.

结论:

基于HA的模板主要在低释放率下表现出骨质导电性.
过度的Ca释放来自更高的HA度会对骨再生产生负面影响.
优化Ca释放对于有效的基于HA的骨组织工程支架至关重要.

关键词:

在 PLATMC 中,混合混合混合的混合.骨再生骨再生酸和酸的作用形骨缺陷是一种形骨缺陷.可以打印的可用性.这是一只子,子.

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