区分莱姆关节炎:基于病例的综述
Ayse Mine Unlu1,2, Nanna Skaarup Andersen3,4,5, Sanne Løkkegaard Larsen3,4,5
1Department of Rheumatology, University Hospital of Southern Denmark, Esbjerg, DK-6700, Denmark. ayse.mine.unlu@rsyd.dk.
Rheumatology international
|May 25, 2024
概括
莱姆病关节炎 (LA) 在丹麦可能比以前认为的更常见. 这项研究发现了PCR确认的病例,并表明诊断延迟有助于其低估.
科学领域:
- 传染性疾病 传染性疾病
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 莱姆关节炎 (LA) 在丹麦的发病率是未知的,之前没有PCR确认的病例.
- 由于与其他类风湿性疾病的相似性,LA存在诊断挑战.
研究的目的:
- 审查已知的LA的发病率和流行率.
- 介绍丹麦PCR确认的LA病例系列.
- 调查丹麦潜在的LA诊断不足情况.
主要方法:
- 针对LA发生/流行情况的MEDLINE和EMBASE的系统文献综述.
- 介绍了来自丹麦南部的六个PCR确认的LA病例.
- 在病例系列中分析诊断延迟和临床表现.
主要成果:
- 文献审查确定了可变的LA患病率 (1.1-280/100,000) 和发病率 (1.1-15.8/100,000在欧洲).
- 丹麦发现了6例PCR确诊的LA病例,诊断延迟长达38个月.
- 患有复发性膝关节关节炎的患者,通常没有典型的暴露史或红血.
结论:
- 丹麦的LA患病率可能高于此前的假设.
- 错误的诊断可能是由于缺乏病史,抗体测试或Borrelia burgdorferi的突液PCR.
- 需要改进的诊断方法来准确识别丹麦的LA病例.
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