澳大利亚老年人的自我评估健康,表观遗传衰老和长期死亡率
Danmeng Lily Li1, Allison M Hodge2,3, Melissa C Southey1,2,4
1Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
GeroScience
|May 25, 2024
概括
自评健康 (SRH) 和表观遗传年龄都是强大的死亡率预测因素. 将这些主观和客观措施结合起来,为评估健康和预测死亡风险提供了一种协同方法.
科学领域:
- 老年学是指老年学的学科.
- 分子生物学分子生物学
- 流行病学 流行病学
背景情况:
- 自评健康 (SRH) 是预测死亡率的主观健康指标,但机制尚不清楚.
- 基因表观年龄,来自DNA甲基化,是生物衰老的客观生物标志物.
- 了解主观和客观健康标志物之间的相互作用对于死亡风险评估至关重要.
研究的目的:
- 调查SRH和表观遗传年龄 (GrimAge,PhenoAge,DunedinPACE) 对所有原因死亡率的综合预测能力.
- 评估SRH和表观遗传衰老之间的潜在相互作用,以预测死亡风险.
主要方法:
- 利用了来自墨尔本协作队列研究的1059名参与者的DNA甲基化数据.
- 计算了三个年龄调整后的表观遗传年龄指标:GrimAge,PhenoAge和DunedinPACE.
- 采用考克斯模型来分析SRH的关联,表观遗传衰老,以及它们与17年死亡率的相互作用.
主要成果:
- SRH显著预测死亡率 (HR=1.29每类增加),经过对表观遗传年龄进行调整后略有减弱.
- 在预测死亡率方面,GrimAge和DunedinPACE与SRH之间发现了显著的相互作用.
- 与表观遗传年龄相关的死亡风险在报告较差SRH的个体中被放大.
结论:
- SRH和表观遗传衰老是死亡率的协同风险因素.
- 整合主观 (SRH) 和客观 (表观遗传年龄) 的健康评估,可以提高整体健康评估.
- 这些发现支持开发衰老的分子标记物,以改善健康评估.
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