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Updated: Jun 25, 2025

Methods to Classify Cytoplasmic Foci as Mammalian Stress Granules
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压力颗粒局部化的USP8通过DDX3XX的deubiquitination强化了cGAS介导的I型干扰性病变

Xuejing Zhang1, Lulu Han1, Jinxiu Hou1

  • 1Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong 250012, China.

Cell reports
|May 25, 2024
PubMed
概括

USP8在压力颗粒中二基化DDX3X,增强循环GMP-AMP合成酶 (cGAS) 凝结和激活. 抑制USP8为治疗cGAS介导的自身免疫性疾病 (如狼) 提供了潜在的策略.

关键词:
科普:分子生物学 分子生物学

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