聚乙烯微塑料会扰乱母亲的葡萄糖平衡,并导致不良妊娠结果
Ruiying Zhang1, Yueying Feng1, Penghui Nie2
1The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330000, China; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China.
Ecotoxicology and environmental safety
|May 25, 2024
概括
在怀孕期间暴露于聚烯微塑料 (PS-MPs) 引起了小鼠的胎盘问题和胎儿生长问题. 此外,PS-MP还导致肝功能障碍和胰岛素抵抗,突出显示了妊娠后果的风险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 生殖生物学 生殖生物学
背景情况:
- 微塑料 (MP) 是普遍存在的环境污染物,具有潜在的毒性影响.
- 新出现的证据将国会议员与代谢障碍联系起来.
- 孕妇特别容易受到环境毒素的影响,影响母亲和胎儿的健康.
研究的目的:
- 调查聚烯微塑料 (PS-MPs) 在怀孕期间对母亲和胎儿健康的影响.
- 阐明PS-MP诱导的代谢异常和不良妊娠结果的潜在机制.
主要方法:
- 建立了一个孕期老鼠模型.
- 在怀孕期间,小鼠接受了不同度 (0.1,1,10 mg/L) 的PS-MPs (1μm).
- 评估了胎盘功能,胎儿生长,肝功能,葡萄糖代谢和关键分子通路 (SIRT1/IRS1/PI3K).
主要成果:
- 暴露于PS-MPs导致胎盘功能障碍和胎儿生长迟缓.
- 观察到显著的葡萄糖代谢障碍,肝功能下降,肝炎和氧化应激.
- PS-MPs抑制了肝脏SIRT1/IRS1/PI3K通路,与增加的脂多糖 (LPS) 有关.
- 胰岛素抵抗和不良妊娠结果与PS-MP暴露有关.
结论:
- PS-MPs通过胎盘功能障碍,胎儿生长迟缓和代谢障碍诱导不良妊娠结果.
- 该机制涉及通过增加肝脏LPS激活炎症反应和氧化应激,抑制SIRT1/IRS1/PI3K通路.
- 这些发现为预防与环境相关的妊娠糖尿病和相关的妊娠并发症提供了基础.
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