欧洲首例宏循环乳耐药Dirofilaria immitis病例 - 引起关注
Donato Traversa1, Anastasia Diakou2, Mariasole Colombo1
1Department of Veterinary Medicine, University of Teramo, 64100, Teramo, Italy.
概括
欧洲首例宏环乳耐药心虫 (Dirofilaria immitis) 病例是在从美国进口的狗身上发现的. 这凸显了耐药菌株在全球传播的风险,以及需要谨慎监测的必要性.
科学领域:
- 兽医寄生虫学 兽医寄生虫学
- 分子流行病学分子流行病学
- 抗寄生素耐药性 抗寄生素耐药性
背景情况:
- 心病 (Dirofilaria immitis) 是一种重要的狗寄生病,需要昂贵和复杂的治疗方法.
- 宏循环乳 (MLs) 有效预防,但在美国出现了耐ML的D. immitis菌株.
- 耐药菌株可能蔓延到全球其他地区,包括欧洲,这一问题越来越令人担忧.
研究的目的:
- 报告欧洲首个记录的对ML耐药D. immitis在狗中的病例.
- 为了基因鉴定D. immitis菌株,以确认ML耐药性.
- 强调进口耐药心虫菌株的风险和需要加强监测.
主要方法:
- 一只从美国进口到意大利的狗检测出D. immitis阳性,尽管每月接受ML预防.
- 微菌抑制试验表明一种潜在的ML耐药菌株.
- 滴滴数字PCR用于分析微细菌DNA,以检测与ML耐药性相关的特定单核酸多态 (SNP).
主要成果:
- 基因分析揭示了微细菌DNA中的SNP1和SNP7的ML耐药基因型.
- 这些遗传标记与一种抗ML的D. immitis菌株一致.
- 这只狗很可能在进口到欧洲之前在美国被感染.
结论:
- 这一案例证实了对ML耐药的D. immitis在欧洲的进口和存在.
- 在非特有地区存在这些耐药菌株的传染和传播的现实风险.
- 对于早期检测和控制,对来自有记录ML耐药性的地区的流浪狗进行警监测至关重要.
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