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Updated: Jun 25, 2025

Cecal Ligation and Puncture-induced Sepsis as a Model To Study Autophagy in Mice
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调节细胞死亡中的GSDMD:败血症的新型治疗标

Xiangli Ma1, Yujie Lin1, Ling Zhang1

  • 1Department of Emergency Medicine, Lanzhou University Second Hospital, Lanzhou, China.

International immunopharmacology
|May 25, 2024
PubMed
概括

加斯德明D (GSDMD) 调节细胞死亡,有助于败血症的器官损伤. 准GSDMD提供了潜在的新的败血症治疗方法.

关键词:
GSDMDMD的总体发展目标是什么网络 网络 网络 网络热灭菌的发生.调节的细胞死亡.败血症 这是一种败血症.

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Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
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