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Updated: Jun 25, 2025

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
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抗真菌climbazole改变了哺乳动物细胞中的androgenic通路

Dieynaba Ndiaye1, Marie Perceau1, Mylène Lorcin1

  • 1French Research and Safety Institute for the Prevention of Occupational Accidents and Diseases (INRS), Toxicology and Biomonitoring Division, Vandoeuvre les Nancy, France.

Toxicology in vitro : an international journal published in association with BIBRA
|May 25, 2024
PubMed
概括

抗真菌剂Climbazole (CBZ) 破坏类固醇激素的产生,并阻断哺乳动物细胞中的雌激素和雄激素受体. 这项研究揭示了其内分泌干扰潜力和作用机制.

关键词:
雄激素受体的受体 雄激素受体在CYP17 A1中.气候变化造成的危害内分泌干扰 干扰内分泌系统雌激素受体的受体是什么类固醇的产生.

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Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
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