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肠道炎症标志物,饮食和芬兰儿童岛屿自身免疫的风险 - - 一项嵌套的病例控制研究
Tuuli Ei Salo1, Leena Hakola2, Sari Niinistö3
1Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland.
The Journal of nutrition
|May 25, 2024
概括
婴儿期的人类β-防御素-2 (HBD-2) 的较高水平可能表明岛屿自身免疫性风险增加,这是1型糖尿病的前体. 饮食显著影响儿童的肠道炎症标志物.
科学领域:
- 儿科免疫学 儿科免疫学
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 肠道失生症和肠道透性增加与1型糖尿病自身免疫性有关.
- 肠道炎症在自身免疫的发展中的具体作用尚不清楚.
研究的目的:
- 调查肠道炎症标志物与儿童岛屿自身免疫的风险之间的关联.
- 为了确定饮食因素是否与肠道炎症标志物有关.
主要方法:
- 一项嵌套病例控制研究,涉及75名岛屿自身免疫的儿童和88名芬兰1型糖尿病预测和预防队列的对照.
- 通过3天的食物记录评估饮食摄入量;在6个月和12个月时分析便样本的calprotectin和人类β-defensin-2 (HBD-2).
- 用于评估自身免疫风险的条件后勤回归;用于二次分析的ANOVA,t测试和一般线性模型.
主要成果:
- 在12个月后,人类β-defensin-2 (HBD-2) 显示出与岛屿自身免疫风险增加的边界关联.
- 较高的脂肪摄入与增加的HBD-2相关,而较高的纤维,和摄入与较低的HBD-2相关.
- 饮食因素和母亲的教育调节了HBD-2和自身免疫之间的关联.
结论:
- 婴儿期HBD-2水平升高可能与小岛自身免疫的风险增加有关.
- 饮食成分在生命早期调节肠道炎症状态方面发挥着重要作用.
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