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视网膜神经纤维层光学纹理分析和10-2视觉场评估在玻璃眼

Alireza Kamalipour¹, Sasan Moghimi¹, Pooya Khosravi¹

¹From the Hamilton Glaucoma Center (A.K., S.M., P.K., N.T., C.V., M.A., G.G., T.N., L.M.Z., R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, UC San Diego, La Jolla, California, USA.

American journal of ophthalmology

|May 25, 2024

概括

视网膜神经纤维层 (RNFL) 的光学纹理分析显示,乳头瘤和乳头膜束的缺陷在青光眼中很常见. 这些RNFL缺陷显著增加了相应区域视野敏感度异常的可能性.

科学领域:

眼科医生眼科眼科
神经科学是一个神经科学.
医疗成像医学成像

背景情况:

玻璃眼是一种渐进的视神经病变,其特点是视野 (VF) 损失.
准确检测早期结构损坏对于及时干预至关重要.
视网膜神经纤维层 (RNFL) 缺陷是青光眼损伤的关键指标.

研究的目的:

利用视网膜神经纤维层 (RNFL) 光学纹理分析 (ROTA) 来评估乳头瘤和乳头膜束缺陷与10-2视野 (VF) 灵敏度异常之间的关系.
将RNFL捆绑缺陷信息与24-2 VF数据集成,以预测10-2 VF灵敏度异常的可能性.

主要方法:

一项横截面研究包括了442名参与者的841只眼睛 (健康的眼睛,可疑的眼睛和眼睛).
眼睛接受了24-2和10-2 VF测试以及ROTA的光学一致性断层扫描 (OCT).
使用ROTA划定了RNFL缺陷边界,并评估了特定RNFL捆绑的参与. 多级逻辑回归分析了结构-功能关联.

主要成果:

乳头瘤 (92.1%) 和乳头膜 (37.9%) RNFL捆绑缺陷在青光眼中很常见.
一个覆盖着乳头瘤或乳头膜RNFL束缺陷的10-2 VF位置显示了显著更高的降低灵敏度的可能性 (ORs分别为18.61和20.17).
叠加的RNFL捆绑缺陷提供了比异常24-2VF点更强的10-2VF异常预测.

结论:

乳头瘤和乳头膜RNFL捆绑缺陷在玻璃眼中很常见.
这些RNFL束缺陷的存在显著提高了10-2测试检测到的相应中央视野测试位置异常的概率.

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