痛风患者的骨肌肉质量和质量与非痛风对照:一项计算机断层扫描成像研究
Allyson Covello1, Michael Toprover1, Cheongeun Oh2
1Division of Rheumatology, Department of Medicine, New York University Grossman School of Medicine, 550 First Avenue, New York, NY, USA; Rheumatology Section, NY Harbor Health Care System, New York Campus, United States Department of Veterans Affairs, 423 E 23rd Street, New York, NY, USA.
Joint bone spine
|May 25, 2024
概括
痛风患者的腰部肌肉质量下降,表明与肉症的潜在联系. 肌肉量没有受到影响,但肌肉内的脂肪增加表明痛风的肌肉健康受损.
科学领域:
- 类风湿病学 类风湿病学
- 老年学是一门学科.
- 代谢疾病 代谢疾病
背景情况:
- 痛风与血管和代谢问题有关.
- 萨科佩尼亚会影响其他类风湿性疾病.
- 痛风和肉症之间的关联尚未研究.
研究的目的:
- 评估痛风患者的腰部肌肉质量和数量.
- 为了确定痛风是否与sarcopenia有关.
主要方法:
- 45名痛风患者和25名对照患者 (年龄在45-80岁之间) 的腰椎骨的计算机断层成像.
- 在L3水平测量肌肉数量 (SMA,SMI) 和质量 (SMRA,IMAT区域,IMATI).
- 对psoas和勃起脊柱肌肉的分析.
主要成果:
- 痛风患者的BMI较高,并发症 (脏病,高血压),运动频率较低,血清尿酸和肌素水平较高.
- 痛风患者的腰椎骨肌辐射衰减 (SMRA) 显著减少,表明肌肉质量较差.
- 痛风患者的腰部肌肉间脂肪组织 (IMAT) 面积和指数 (IMATI) 显著增加,表明肌肉脂肪增加.
- 骨肌面积 (SMA) 或指数 (SMI) 没有显著差异,这表明肌肉数量不受常规影响.
结论:
- 与对照组相比,痛风患者的腰部肌肉质量下降.
- 研究结果表明,痛风和肉症之间存在关联,特别是在肌肉质量方面.
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