估计的脉冲波速度预测了心力衰竭患者的死亡率,其中保留了喷射分数
Ruicong Xue1, Jiancheng Zhang1, Zhe Zhen1
1Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China; NHC Key Laboratory of Assisted Circulation and Vascular Diseases (Sun Yat-sen University), Guangzhou, Guangdong, China.
概括
估计的脉冲波速率 (ePWV) 预测了心力衰竭患者的心血管结果,其中包括保留喷射率 (HFpEF) 患者. 在HFpEF中,较高的ePWV独立地与增加的全因和心血管死亡率有关.
科学领域:
- 心脏病学 心脏病学
- 血管生物学 血管生物学
- 临床试验 临床试验
背景情况:
- 动脉硬度 (AS) 是心血管疾病 (CVD) 和死亡率的重要预测因素.
- 估计脉冲波速度 (ePWV) 是一种新的AS参数,在一般和高风险人群中具有既定的预后值.
- 在心力衰竭中,ePWV的预后意义与保存的喷射分数 (HFpEF) 仍然未确定.
研究的目的:
- 调查ePWV在预测HFpEF患者临床结果中的预后价值.
- 确定ePWV是否是HFpEF中死亡率和住院治疗的独立预测因素.
主要方法:
- 从TOPCAT试验中对HFpEF参与者的分析 (n=1764) 与基线ePWV数据.
- 利用考克斯的比例危险模型来评估ePWV与长期临床结果之间的关联.
- 结果包括全因死亡率,心血管死亡率,全因住院治疗和心力衰竭住院治疗.
主要成果:
- 在对混杂因素进行调整后,每1m/s的ePWV增加都与16%的全因死亡风险增加和13%的心血管疾病死亡风险增加有关.
- 与较低的四分位数相比,EPWV最高四分位数 (≥12.806 m/s) 的患者具有明显更高的全因死亡率 (HR: 1.96) 和心血管疾病死亡率 (HR: 1.72) 的风险.
- ePWV证明了HFpEF患者死亡率的独立预后价值.
结论:
- ePWV是HFpEF患者全因和心血管死亡率增加的独立预测因素.
- ePWV 作为一个有价值的预后标志物,用于 HFpEF 群体的不良结果.
- 这些发现支持ePWV在HFpEF患者风险分层中的临床实用性.
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