在晚年双相情感障碍中,与衰老相关的分泌表型指数升高
Tselot Tessema1, Breno S Diniz2, Erica M Vieira3
1Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada.
Journal of affective disorders
|May 25, 2024
概括
患有双相情感障碍 (BD) 的老年人表现出较高的衰老相关分泌表型 (SASP) 指数,表明细胞衰老增加. 这可能与BD中更糟糕的抑郁症状和身体健康有关.
科学领域:
- 老年学是一门学科.
- 精神病学是一个精神病学.
- 细胞生物学 细胞生物学
背景情况:
- 细胞衰老与衰老和疾病有关.
- 与衰老相关的分泌表型 (SASP) 是细胞衰老的关键指标.
- 此前,SASP尚未在患有双相情感障碍 (BD) 的老年人中进行评估.
研究的目的:
- 为了调查老年人患有BD是否与健康对照人相比表现出较高的SASP指数.
- 探索SASP指数得分和BD老年人的临床因素之间的关系.
主要方法:
- 进行了一项横截面研究.
- 包含22种血液蛋白质的SASP指数测量了38名患有BD的老年患者和34名健康对照患者 (HC).
主要成果:
- 在BD组中,SASP指数得分明显高于HC组,即使控制了共变量.
- 在整体样本中,SASP指数得分与年龄增加,抑郁症状严重程度增加和身体疾病负担增加相关.
结论:
- 这项研究提供了第一个证据,证明了老年人患有BD的SASP指数得分升高.
- 研究结果表明,SASP指出的失调的衰老过程可能会导致老年BD患者的临床严重程度和身体健康问题.
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