初级甲状腺功能障碍症和心血管结果之间的关联:系统性审查和元分析
Siang-Ke Kong1, Ming-Chieh Tsai2, Chun-Lin Yeh3
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Mackay Memorial Hospital, Taipei 104, Taiwan.
Bone
|May 25, 2024
概括
初级甲状腺功能障碍症 (PHPT) 增加死亡风险,但甲状腺切除术 (PTX) 降低了这种风险. 这项研究评估了PHPT.
科学领域:
- 内分泌学和新陈代谢学
- 心血管医学 心血管医学
- 外科手术的结果
背景情况:
- 偏甲状腺激素 (PTH) 水平升高与心血管疾病 (CVD) 风险增加有关.
- 原发性副甲状腺炎症 (PHPT) 是一种以过多的PTH产生为特征的疾病.
- PHPT与心血管结果之间的关联需要进一步澄清.
研究的目的:
- 评估PHPT与心血管疾病或心血管 (CV) 死亡风险之间的关联.
- 评估副甲状腺切除术 (PTX) 对PHPT患者死亡率和心血管疾病结局的影响.
主要方法:
- 在PubMed,Embase和ClinicalTrials.gov.gov的系统文献搜索.
- 包括队列研究和随机对照试验,将PHPT患者与普通人群进行比较,并评估PTX结果.
- 由三名调查人员进行独立的数据提取和质量评估.
主要成果:
- 与一般人群相比,PHPT与总死亡率 (RR 1.39) 和心血管死亡率 (RR 1.61) 的风险增加有关.
- 在PHPT患者和普通人群之间没有观察到心血管疾病风险的显著差异 (RR 1.73).
- 副甲状腺切除术 (PTX) 与心血管死亡 (RR 0.75),总死亡 (RR 0.64) 和心血管疾病 (RR 0.92) 的风险降低有关.
结论:
- PHPT与总和心血管死亡的风险增加有关.
- 副甲状腺切除术 (PTX) 显示出保护作用,降低了总死亡,心血管死亡和心血管疾病的风险.
- 高异质性和依赖于较旧的回顾性研究,需要谨慎地解释研究结果.
相关概念视频
Psychoneuroimmunology: Cardiovascular Disease
30
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
30
The Parathyroid Glands
2.1K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.1K
Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Disorders of the Autonomic Nervous System
625
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
625
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
77
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
77
Cardiovascular Drugs: Classification based on Therapeutic Indications
2.8K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
2.8K


