来自Platycodon grandiflorum的多糖类:对它们的提取,结构,修饰和生物活性进行了审查
Yuping Zhang1, Minghao Sun1, Yujia He1
1Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China.
International journal of biological macromolecules
|May 25, 2024
概括
普拉蒂科登格兰迪弗洛勒姆多糖体显示出显著的免疫增强和保护作用. 本综述系统地总结了它们的提取,特性和生物活动,帮助未来的药物和健康产品开发.
科学领域:
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
- 免疫学 免疫学 免疫学
背景情况:
- 普拉蒂科登大花 (P. grandiflorum) 是一种传统的草药,用于食品和医药.
- 多糖是P. grandiflorum中的主要活性成分.
- 现有研究强调了它们多样化的药理作用.
研究的目的:
- 为提供P. grandiflorum多糖化物研究的全面审查.
- 涵盖提取,净化,表征,修饰和生物活动.
- 确定研究缺口,并建议未来的方向.
主要方法:
- 关于P. grandiflorum polysaccharides的科学文章的文献评论.
- 综合有关制备,结构分析和生物活性的信息.
- 对当前的研究方法和研究结果进行批判性评估.
主要成果:
- P. grandiflorum的多糖体表现出免疫刺激,抗氧化,抗肝损伤,抗亡和抗瘤活动.
- 报道了各种提取,净化和表征的方法.
- 存在结构修改以增强生物活性的潜力.
结论:
- 需要对P. grandiflorum多糖的系统摘要.
- 进一步的研究应侧重于阐明结构-活动关系.
- 这些多糖化合物对制药和营养食品应用具有前景.
更多相关视频
相关概念视频
Cellulose and Pectic Polysaccharides
3.5K
Every plant cell has a cell wall that protects the cell, provides structural support, and gives the cell shape. Cellulose, the main structural component of the plant cell wall, makes up over 30% of plant matter. It is the most abundant organic compound on earth. Cellulose is an unbranched polysaccharide composed of linear chains of glucose molecules linked by β (1→4) glycosidic bonds.
As a cell matures, its cell wall specializes according to its type. For example, the...
As a cell matures, its cell wall specializes according to its type. For example, the...
3.5K
Protein Glycosylation
6.9K
Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
Glycosylation occurs in...
6.9K
Oligosaccharide Assembly
2.8K
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
Multiple sugar molecules that may or may...
2.8K


