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纳米体脂质体作为新型癌症疫苗平台,有效刺激T细胞免疫力

R G Bouma¹, M K Nijen Twilhaar¹, H J Brink¹

¹Department of Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam 1081 HV, the Netherlands; Amsterdam institute for Immunology and Infectious Diseases, Cancer Immunology, Amsterdam, the Netherlands; Cancer Center Amsterdam, Cancer Immunology, Amsterdam, the Netherlands.

International journal of pharmaceutics

|May 25, 2024

概括

新型纳米体脂质体增强抗原呈现细胞 (APC) 吸收癌症疫苗,改善T细胞激活和抗瘤免疫反应. 这种有针对性的疫苗接种策略可以促进癌症治疗的免疫启动.

科学领域:

免疫学免疫学免疫学
纳米技术纳米技术
在瘤学瘤学.

背景情况:

抗原呈现细胞 (APC) 对于启动抗瘤免疫反应至关重要.
目前的癌症疫苗策略通常依赖于APC的非特异性抗原吸收.
提高APC向是优化疫苗疗效的关键.

研究的目的:

开发一种使用纳米体结合脂质体的新型疫苗接种策略,以针对APC吸收.
评估CD169和DC-SIGN特定的纳米体脂质体在准APC中的效率.
评估这种有针对性的输送对T细胞激活和免疫启动的影响.

主要方法:

癌症抗原的结合与CD169或DC-SIGN特定的纳米体功能化的脂质体.
使用人类和小鼠APC进行体外和体内研究,以评估脂质体吸收.
对纳米体脂质体疫苗接种的T细胞激活和天真T细胞原始化的评估.

主要成果:

与对照脂质体相比,纳米体脂质体的向人类和小鼠APC的吸收率显著更高.
CD169纳米体脂质体表现出由人类APCs增强的T细胞激活.
用纳米体脂质体接种疫苗在小鼠模型中有效刺激了天真T细胞原始化.

结论:

纳米体结合脂质体代表了针对性癌症疫苗接种的有希望的战略.
这种方法增强了APC吸收和随后的T细胞反应,这对于抗瘤免疫是至关重要的.
纳米体脂肪体平台可以适应其他APC受体,以引起对癌症抗原的强有力的免疫反应.

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Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.