茄子种子多糖化物-甲胺插入:较高的眼睛保留,缓慢释放,以及对角膜烧伤的有效性
Varaprasad R Regu1, Vinit Gohel1, Mahendra Gaur1
1Drug Development and Analysis Laboratory, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be) University, Bhubaneswar 751003, Odisha, India.
International journal of pharmaceutics
|May 25, 2024
概括
这项研究开发了一种没有防腐剂的眼部插入剂,用于治疗眼部烧伤的美特福林 (MET). 插入,使用茄子种子多糖化物 (TSP),增强MET.
科学领域:
- 眼科医生 眼科 眼科
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 梅特福林 (MET) 由于其类基因机制,显示出对眼部烧伤的治疗潜力.
- MET的高水溶性导致鼻液的迅速排水,限制眼睛的保留和有效性.
- 开发持续释放配方对于有效的眼科MET应用至关重要.
研究的目的:
- 设计和评估一种新的眼镜插入物,用于持续输送甲胺 (MET).
- 为了增强眼睛表面保留和治疗MET治疗眼睛烧伤的疗效.
- 研究用于眼科药物输送的天然聚合物的粘膜粘合性.
主要方法:
- 在天然聚合物的化分析,用于粘素结合和MET相互作用.
- 开发了一种Metformin (MET) 眼镜插入剂,使用一种溶剂造方法,使用茄子种子多糖化物 (TSP) 和甘醇 (PG).
- 插入稳定性 (ICH指南) 的评估,兼容性,体外药物释放,子体内眼睛保留和角膜烧模型中的疗效.
主要成果:
- 茄子种子多糖化物 (TSP) 显示出粘膜粘合和与甲胺 (MET) 相互作用的潜力.
- 开发的MET眼镜插件表现出足够的稳定性和无菌性.
- 在体内研究表明,MET的长时间眼部保留 (10-12小时) 和在体内持续释放 (30小时).
- 在子的临床前角膜性烧伤模型中观察到显著的疗效.
结论:
- 用麻种子多糖化物 (TSP) 配制的Metformin (MET) 眼镜插入剂为持续的眼部药物输送提供了一个有希望的策略.
- TSP的粘膜粘合特性有助于增强MET的眼睛保留.
- 这种无防腐剂配方显示出有效管理眼部烧伤的巨大潜力.
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