黄 - - 对抗菌感应测试的感应器YeastOne和Vitek 2 AST系统的比较 - - 一个单一中心的经验
Sampada A Patwardhan1, Parikshit S Prayag2, Rajeev N Soman2
1Department of Microbiology, Deenanath Mangeshkar Hospital, Pune, India.
Indian journal of medical microbiology
|May 25, 2024
概括
商业抗真菌敏感性测试 (AFST) 系统显示出Candida auris. 的差异. 维特克2和Sensititre YeastOne (SYO) 方法对沃里可纳,安福特里辛B和卡斯福金产生不同的结果,影响了临床决策.
科学领域:
- 医学真菌学 医学真菌学
- 临床微生物学 临床微生物学
- 传染性疾病 传染性疾病
背景情况:
- 黄是一种新兴的病原体,导致候选血病和侵入性感染.
- 准确的抗真菌敏感性测试 (AFST) 对于管理C. auris感染至关重要.
研究的目的:
- 为了比较Vitek 2和Sensititre YeastOne (SYO) 方法对Candida auris血流分离物的AFST的性能.
- 确定两种系统之间解释易感性结果的潜在差异和挑战.
主要方法:
- 测试了47个Candida auris血流隔离物.
- 同时使用Vitek 2和Sensititre YeastOne (SYO) 方法对AFST进行测试.
- 对最小抑制度 (MIC) 的评估和对抗性/敏感性的解释.
主要成果:
- 所有的分离物是抗可纳的;25.5%的分离物表现出泛醇耐药性.
- 与SYO相比,Vitek 2的Vitek-to-SYO MIC错误率 (VME) (76.1%) 和Vitek-to-SYO MIC错误率 (VME) (76.1%) 较低,而Vitek 2的Vitek-to-SYO MIC错误率则较低.
- SYO表明对anidulafungin和micafungin的敏感性,而Vitek 2显示了更高的micafunginMIC和23.5%的MIC错误率 (ME).
- 卡斯波丁的SYO结果受到"效应" (21小时后的矛盾生长) 的影响,敏感度仅为28.2%.
- 与SYO相比,Vitek 2表现出更高的对乙氨酸的耐药性率,ME率为25.6%,比SYO.
结论:
- 实验室必须意识到潜在的ME和VME与维特克2对安福特里辛B和voriconazole.
- "效应"对于与SYO结合的菌素需要仔细解释.
- 这些差异凸显了在C. auris AFST.中需要特定方法的认识.
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