在长期COVID的医疗保健工作者中通过缓慢呼吸调节心率变化:一项病例控制研究
Marcella Mauro1, Luca Cegolon1, Nicoletta Bestiaco1
1Unit of Occupational Medicine, Department of Medical Sciences, University of Trieste, Trieste, Italy.
The American journal of medicine
|May 25, 2024
概括
长期COVID患者表现出自主神经系统功能下降,特别是巴罗反射敏感性受损. 缓慢的呼吸练习改善了这一功能,这表明了长期COVID自主功能障碍的潜在治疗方法.
科学领域:
- 心脏病学 心脏病学
- 自主神经科学 自主神经科学
- 公共卫生 公共卫生
背景情况:
- 长期COVID是一个持续的COVID-19后综合征,显著影响日常生活和工作.
- 自主神经系统 (ANS) 失衡是长期COVID症状的疑似原因之一.
- 长期COVID患者的医疗保健工作者 (HCW) 的心血管自主功能需要进一步调查.
研究的目的:
- 在经历长期COVID的HCW中调查心血管自主功能.
- 评估慢节奏呼吸 (SPB) 在长期COVID患者中调节自主功能的有效性.
- 为了比较长期COVID,从未感染过和完全康复的个体之间的自主功能.
主要方法:
- 从2022年12月到2023年3月评估了126名HCW (58名长期COVID,53人从未感染,14人康复).
- 使用经过验证的问卷进行评估的全球健康和精神症状.
- 在自发和慢节奏呼吸 (SPB) 过程中,通过光电脉学测量心率变化.
主要成果:
- 与对照人群相比,长期COVID HCWs在自发呼吸期间表现出明显更多的精神症状和降低的巴罗反射灵敏度 (迈耶波) (P = .027).
- 在长期COVID患者中,SPB显著改善了巴罗反射敏感性,接近对照组 (P = .09) 中所见的水平.
- 两组之间没有观察到其他心率可变性参数的显著差异.
结论:
- 长期的COVID与静止血管调节的减少和巴罗反射灵敏度的受损有关.
- 在长期COVID患者中,SPB显示了改善巴罗反射敏感性的潜力.
- 需要进行进一步的长期研究,以确定重复呼吸练习是否可以恢复血管反应能力并减轻心血管风险.
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