在牙中产前金属和金属化物混合物之间的关联以及儿童肺功能减少
Maria Jose Rosa1, Chris Gennings1, Paul Curtin2
1Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, USA.
The Science of the total environment
|May 25, 2024
概括
产前接触金属混合物与儿童肺功能减弱有关,特别是在出生前的关键窗口期间. 和是主要的贡献者,对男性的影响更为明显.
科学领域:
- 环境健康 环境健康
- 儿科肺病学 儿科肺病学
- 毒理学 毒理学 毒理学
背景情况:
- 金属化物与儿童肺功能有关,但产前综合作用尚未得到充分研究.
- 婴儿的性别可能会影响金属对肺部发育的影响.
研究的目的:
- 用牙生物标志物和儿童肺功能来评估子宫内和生命早期的金属暴露.
- 调查这些关联中的潜在基于性别的差异.
主要方法:
- 在墨西哥城进行的长度出生队列研究 (PROGRESS) (n=291).
- 牙金属含量 (As,Cd,Co,Cu,Mn,Ni,Pb) 测量时间为出生前15周至出生后15周.
- 肺功能 (FVC z-scores) 在8-14岁时进行评估;使用滞后加权量素和 (LWQS) 回归分析,按性别分层.
主要成果:
- 一个产前暴露窗口 (出生前12-15周) 显示了与较低的FVCz-score相关的混合效应.
- (Cd) 和 (Mn) 是混合物的影响的主要贡献者 (70%).
- 观察到性别变化;影响在男性中更为明显,Cd,Mn和 (Pb) 在这个层中占主导地位.
结论:
- 产前接触金属混合物会对儿童的肺功能产生负面影响.
- 确定关键暴露窗口和考虑性别对于了解金属对肺部健康的影响至关重要.
相关概念视频
The Periodic Table and Organismal Elements
178.1K
Overview
178.1K
Types of Toxins
1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
272
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
272
Attention-Deficit/Hyperactivity Disorder
55
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
55


