内源性瘤性KRAS表达增加了接近二倍体的hTERT RPE-1细胞中的细胞增殖和运动性

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Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans
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Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans

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Naushin L Hindul1, Lauren R Abbott1, Sumaya M D Adan1

  • 1Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.

The Journal of biological chemistry
|May 25, 2024
PubMed
概括

新的同源细胞系具有KRAS突变 (KRASG12V/+,KRASG12C/+,KRASG12D/+) 被创建以研究瘤性RAS信号. 这些模型揭示了不同的细胞行为和药物反应,有助于开发向癌症疗法.

关键词:
细胞循环中的细胞循环.细胞移动性的细胞移动性细胞的增殖细胞的增殖.细胞信号传递是细胞的信号传递.焦点粘附的焦点粘附.小型的GTP酶.

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