2型糖尿病患者的残留胆固醇和高尿血之间的相关性:一个横截面研究
Hainiao Lin1, Jing Xu2, Chenhuai Teng3
1Department of Emergency Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Lipids in health and disease
|May 25, 2024
概括
升高的残留胆固醇 (RC) 与2型糖尿病 (T2DM) 患者的高尿血症 (HUA) 有显著联系. 与传统的脂质指标相比,RC证明了HUA的优越可预测性.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 剩余胆固醇 (RC) 是已知的代谢综合征 (Mets) 的风险因素.
- 在2型糖尿病 (T2DM) 中,RC和高尿素血 (HUA) 之间的关系尚未得到充分证实.
- 这项研究调查了T2DM患者中RC和HUA之间的关联.
研究的目的:
- 探索2型糖尿病 (T2DM) 患者残留胆固醇 (RC) 和高尿素血 (HUA) 之间的相关性.
- 评估与其他脂质参数相比,HUA的RC的预测值.
主要方法:
- 包括从2020年到2022年的2956名T2DM患者.
- 使用了斯皮尔曼相关性,多重物流回归,ROC曲线分析和通用的平滑曲线拟合.
- 定义的正常总胆固醇 (TC) 是<5.18 mmol/L.
主要成果:
- 在T2DM患者中,RC和尿酸之间发现了显著的正相关性 (斯皮尔曼的rho=0.279,P<0.001).
- 多重后勤回归证实了RC和HUA之间的独立正相关性 (OR = 1.63).
- 与LDL-C,TG,HDL-C和TC相比,RC显示了HUA的最高预测值 (AUC = 0.658),与LDL-C,TG,HDL-C和TC相比. 观察到非线性相关性,特别显著在女性和那些正常的TC.
结论:
- 在T2DM患者中,升高的RC与HUA显著和积极相关.
- 与传统的脂质指数相比,RC证明了HUA的优越可预测性.
- 在T2DM中,RC可以作为评估HUA风险的有价值生物标志物.
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