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便Coprococcus,隐藏在腹部症状后面的细肠细菌过度生长的患者

Huaizhu Guo¹, Yuzhu Chen¹, Wenxin Dong²

¹Department of Gastroenterology, Peking University Third Hospital, Beijing, China.

Journal of translational medicine

|May 25, 2024

概括

小肠细菌过度生长 (SIBO) 与特定的肠道细菌 (如Coprococcus_2) 有关,这与症状严重程度相关. 无症状的个体有阳性呼吸测试显示不同的微生物概况,表明不同的肠道生态系统动态.

科学领域:

胃肠病学胃肠病学
微生物组研究微生物组研究
代谢分析分析 (Metabolic Profiling) 是一种对代谢进行分析的方法.

背景情况:

小肠细菌过度生长 (SIBO) 的特点是细肠中的过度细菌殖民.
气和甲呼吸测试是常见的非侵入性SIBO诊断.
阳性呼吸试验可以发生在无症状个体中,使诊断复杂化.

研究的目的:

调查SIBO中临床症状和肠道失调症之间的关系.
为了确定SIBO的潜在便微生物生物标志物.
为了比较有症状的SIBO患者的微生物概况,无症状的积极呼吸试验个体 (PBT) 和健康的对照 (HC).

主要方法:

16S rRNA amplicon测序用于分析便微生物概况.
微生物多样性的比较 (香农指数) 和基属层面的组成.
微生物共发生网络和代谢途径的分析 (KEGG数据库).

主要成果:

在SIBO患者中,预测功能的Shannon指数下降和基因丰度变化 (Bacteroides下降,Coprococcus_2增加,独特的Butyrivibrio).
在SIBO患者中,Coprococcus_2的丰度与症状严重程度正相关.
与SIBO患者相比,无症状的PBT个体表现出独特的Veillonella和更密集的微生物共发生网络.
在SIBO患者中观察到叶酸和氨基酸代谢途径的减少.

结论:

便微生物群的改变和预测的代谢变化在SIBO中很明显.
布蒂里维布里奥和Coprococcus_2与SIBO症状的发展有关,Coprococcus_2可能作为SIBO生物标志物.
无症状的PBT个体具有独特的微生物组,它们复杂的微生物相互作用可能会赋予生态系统的稳定性.
需要进一步的研究来验证叶酸和氨基酸代谢在SIBO中的作用.

关键词:

我们的肠道微生物组.气和甲呼吸试验网络分析网络分析糖溶性细菌是一种细菌.小肠细菌的过度生长细肠细菌的过度生长

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