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系统审查和元分析:质子抑制剂稍微降低了慢性咳的严重程度.

Diana-Elena Floria1,2,3, Mahmoud Obeidat1,4, Sarolta Beáta Kávási1,5

  • 1Centre for Translational Medicine, Semmelweis University, Üllői Út 26, Budapest, 1085, Hungary.

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概括
此摘要是机器生成的。

质子抑制剂 (PPI) 轻微减少与酸性反流相关的慢性咳的严重程度. 这一元分析发现,无论治疗持续多长时间,PPI都提供了适度的益处.

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科学领域:

  • 胃肠病学 胃肠病学
  • 肺部病理学 肺部病理学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 慢性咳被认为是胃食道逆流症 (GERD) 的潜在食道外表现.
  • 抑制酸性药物,特别是质子抑制剂 (PPI),经常用于管理与GERD相关的症状,包括慢性咳.
  • 在治疗非特异性慢性咳时,PPI的有效性仍然是研究的主题.

研究的目的:

  • 进行一项元分析,评估抑制酸性药物对患有非特异性慢性咳的成年人影响.
  • 评估与安慰剂相比PPI在减少咳严重程度和改善生活质量的影响.
  • 调查治疗时间是否会影响与GERD相关的慢性咳的治疗反应.

主要方法:

  • 系统搜索三个数据库,查找截至2022年11月1日发布的安慰剂对照随机试验 (RCT).
  • 包括11个双盲,安慰剂控制的RCT,评估持续咳的PPI.
  • 应用随机效应模型来计算咳严重程度和生活质量的标准化平均差异 (SMD) 与95%置信区间 (CI).

主要成果:

  • 与安慰剂相比,质子抑制剂显示咳严重程度有统计学意义的,尽管轻微,但降低 (SMD 0.33;95% CI 0.05;0.61).
  • 单独患有非特异性慢性咳的患者与患有喉回流的患者之间没有观察到治疗反应的显著差异.
  • 长期治疗时间 (4,6,8和12周) 并没有显著改善症状,SMD范围为0.31至0.34.
  • 综合分析表明,使用PPI对生活质量没有显著改善 (SMD 0.39; 95% CI -0.51; 1.29).

结论:

  • 质子抑制剂在减少非特异性慢性咳的严重性方面提供了轻微的好处.
  • 个人保护剂在治疗这种疾病中的有效性似乎独立于治疗持续时间.
  • 可能需要进一步的研究,以充分阐明PPI的作用,并优化与GERD相关的慢性咳的治疗策略.