在体外和体外,聚胺胺) 纳米乳液对 Echinococcus granulosus 的原始杀伤作用
Dina Aboelsoued1, Nagwa I Toaleb2, Sally Ibrahim3
1Department of Parasitology and Animal Diseases, Veterinary Research Institute, National Research Centre, Dokki, Giza, Egypt. Dr.Dina.Aboelsoued@gmail.com.
Scientific reports
|May 25, 2024
概括
在实验室测试中,聚胺胺 (PAMAM) 纳米乳液有效地杀死了酸原体. 这种PAMAM纳米乳液在体外和体外环境中显示出作为水症治疗的前景.
科学领域:
- 纳米技术纳米技术
- 寄生虫学的寄生虫学
- 兽医医学 兽医医学 兽医医学
背景情况:
- 由 Echinococcus granulosus 引起的水性增生症对全球健康和经济构成重大挑战.
- 现有的水症治疗方法有局限性,需要开发新的治疗药物.
- 聚胺胺胺 (PAMAM) 纳米乳液代表了对寄生虫感染的潜在新类药物.
研究的目的:
- 为了合成和表征聚胺胺 (PAMAM) 纳米乳液.
- 评估PAMAM纳米乳液在体外和体外对抗 Echinococcus granulosus 的原体杀效应.
主要方法:
- 使用动态光散射来合成和表征PAMAM纳米乳液的粒子大小和泽塔潜力.
- 在体外和体外的原始杀性活性被评估,使用欧染料排除试验和扫描电子显微镜 (SEM).
- 试剂暴露于不同度 (0.5-2 mg/mL) 和时间点 (5-30 分钟) 的 PAMAM 纳米乳液.
主要成果:
- 在体外和体外试验中,PAMAM纳米乳液在体外和体外试验中都表现出显著的度和时间依赖的原始杀效应.
- 在体外,在20分钟后达到2 mg/mL的100%,在30分钟后达到1和1.5 mg/mL的100%.
- 在体外,100%的死亡率在30分钟后在2毫克/毫升下观察到,通过SEM观察到原生体的体,和吸的显著损伤.
结论:
- PAMAM纳米乳液表现出强烈的原始杀性活性,使其成为水症治疗的有希望的药物.
- 纳米乳液在短时间暴露时表现出高效率,这表明了快速治疗作用的潜力.
- 进一步的体内研究和临床前试验是有必要的,以探索PAMAM纳米乳液对水囊的临床应用.
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