侧侧神经元FoxP2神经元调节呼吸系统对高头的反应
Satvinder Kaur1, Nicole Lynch1, Yaniv Sela1
1Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Nature communications
|May 25, 2024
概括
研究人员在副核 (PB) 中确定了特定的神经元,这些神经元调节呼吸和兴奋. 准FoxP2神经元可能会改善睡眠呼吸暂停的呼吸,而不会引起唤醒.
科学领域:
- 神经科学是一个神经科学.
- 呼吸系统生理学 呼吸系统生理学
- 睡眠科学 睡眠科学
背景情况:
- 副手臂核 (PB) 在心肺呼吸控制和兴奋中起着至关重要的作用.
- 在PB中的二氧化碳敏感神经元参与检测超,并启动呼吸和兴奋反应.
- 在PB中发现了两种不同的CO2敏感神经元群:PBel (CGRP) 和PBcl/KF (FoxP2).
研究的目的:
- 为了研究FoxP2-表达神经元在中央横向 (PBcl) 和Kölliker-Fuse (KF) 副核 (PB) 的亚核在呼吸控制和唤醒中的作用.
- 为了区分PBcl/KF(FoxP2) 神经元与之前识别的PBel(CGRP) 神经元的功能.
主要方法:
- 在雄性小鼠中利用了基因操纵和光遗传技术.
- 在不同睡眠和清醒状态以及对CO2的反应中测量了PBcl(FoxP2) 神经元中的细胞内水平.
- 研究了光激活或光抑制PBcl(FoxP2) 神经元对呼吸的影响.
- 评估了PB/KF(FoxP2) 神经元遗传删除对呼吸系统对CO2反应的影响.
主要成果:
- 大多数PBcl和KF亚核中的CO2敏感神经元表达转录因子FoxP2,并向髓呼吸道部位投射.
- PBcl(FoxP2) 神经元在清醒,REM睡眠和NREM睡眠期间对高CO2的反应中表现出细胞内的增加.
- 通过光激活PBcl(FoxP2) 神经元,增加了呼吸.
- 通过光抑制PBcl ((FoxP2) 神经元或遗传删除PB/KF ((FoxP2) 神经元,降低了对CO2的呼吸反应,但没有阻止唤醒.
结论:
- PBcl/KF(FoxP2) 神经元对于呼吸系统对CO2的反应至关重要.
- 准PBcl/KF(FoxP2) 神经元为睡眠呼吸暂停等疾病提供了潜在的治疗策略,旨在增加CO2反应能力,同时最大限度地减少不必要的唤醒.
- 涉及增加PBcl/KF(FoxP2) 活性和抑制PBel(CGRP) 神经元的综合方法可能有助于通过解决低通风和过度唤醒来管理睡眠呼吸暂停.
更多相关视频
05:28Electrophysiology on Isolated Brainstem-spinal Cord Preparations from Newborn Rodents Allows Neural Respiratory Network Output Recording
Published on: November 19, 2015
8.6K
05:45Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
Published on: October 25, 2019
5.9K
相关概念视频
01:18Neural Control of Respiration
2.4K
The neural regulation of respiration is a meticulously coordinated process primarily controlled by the respiratory centers located within the brainstem. These centers, composed of specialized neurons, transmit nerve impulses that control the contraction and relaxation of our respiratory muscles.
Respiratory Centers in the Brainstem
Two primary areas comprise the respiratory center: the medullary respiratory center in the medulla oblongata and the pontine respiratory group in the pons. The...
Respiratory Centers in the Brainstem
Two primary areas comprise the respiratory center: the medullary respiratory center in the medulla oblongata and the pontine respiratory group in the pons. The...
2.4K
01:22Physiology of Respiration II: Neurogenic Control of Respiration
633
The neurogenic control of respiration coordinates various neural networks and pathways to regulate breathing rate and depth, meeting the body's oxygen and carbon dioxide exchange requirements. This system adapts to physiological and environmental conditions, ensuring optimal breathing patterns.
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
633
01:31Chemical Factors Affecting Respiration Centers
1.1K
Chemical factors such as changing CO2, O2, and H+ levels in arterial blood play a critical role in influencing respiration depth and rates. These variations are detected by chemoreceptors—specialized sensors located in two primary body areas. Central chemoreceptors are found throughout the brain stem, including the ventrolateral medulla, while peripheral chemoreceptors are located in the aortic arch and carotid arteries.
CO2 has a potent influence on respiration and is strictly regulated....
CO2 has a potent influence on respiration and is strictly regulated....
1.1K
01:23Physiological Control of Respiration
2.0K
Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
2.0K
01:17Other Factors Affecting Respiration Centers
831
Breathing is primarily an involuntary activity regulated by the brainstem respiratory centers. However, it can also be consciously controlled, allowing us to hold our breath or take deeper breaths when needed. This voluntary control is facilitated by the cerebral motor cortex, which bypasses the medullary centers to stimulate the respiratory muscles directly.
However, the ability to hold one's breath voluntarily is not limitless. When the CO2 concentration in the blood reaches a critical...
However, the ability to hold one's breath voluntarily is not limitless. When the CO2 concentration in the blood reaches a critical...
831
01:30Acute Respiratory Failure-III
178
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
178