在巴西空军战斗飞行员中,与飞行时间相关的代谢灵活性
Alanny Cristine Dos Santos Pinheiro1, Grace Barros de Sá2, Roberta Verissimo França de Oliveira1
1Laboratório de Metabolômica (LabMet), Universidade Do Estado Do Rio de Janeiro (UERJ), Instituto de Biologia Roberto Alcântara Gomes, Rio de Janeiro, RJ, Brazil.
概括
战斗机飞行员经历免疫代谢失调,特别是那些飞行时间较短的飞行员. 积累飞行小时似乎抵消了这些影响,这表明飞行员健康和培训的影响.
科学领域:
- 航空航天医学 航空航天医学
- 代谢学 代谢学 代谢学
- 免疫学 免疫学 免疫学
背景情况:
- 战斗机飞行员面临着许多压力因素,包括身体和心理上的劳累,昼夜干扰和环境因素.
- 这些压力因素可以损害生理补偿机制和代谢灵活性,即使在严格选择的个体.
研究的目的:
- 为了比较不同飞行经验的巴西F5战斗机飞行员的新陈代谢概况,与使用基于核磁共振 (NMR) 的新陈代谢分析的非飞行员对照组进行比较.
- 为了测试战斗飞行员表现出与其累积飞行时间相关的代谢灵活性的假设.
主要方法:
- 34名巴西战斗机飞行员的队列根据飞行经验 (<1,100小时和≥1,100小时) 被分为两组,与21名非飞行员军人进行了比较.
- 数据收集包括人体测量测量,全血细胞计,脂质概况,氧化应激标志物和基于血清NMR的代谢学.
主要成果:
- 与对照人群相比,飞行员的白细胞,中性粒细胞,淋巴细胞,α-葡萄糖,乳酸盐,谷氨酸,基胺,基胺和氨酸水平降低.
- 飞行员表现出比对照人群更高的异酸盐度.
- 在非飞行员中观察到乳酸和氨基酸之间的显著相关性,在经验丰富的飞行员中观察到乳酸和谷氨酸之间的显著相关性.
结论:
- 与非飞行员相比,具有较低飞行经验的战斗机飞行员表现出免疫代谢失调.
- 飞行时间的积累似乎减轻了这些免疫代谢变化.
- 调查结果可以为健康保护和战斗机飞行员的作战训练策略提供信息.
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