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肤色患者的皮肤癌相关的基因皮肤病:一篇综述
Sherwin Fazelpour1, Sandhya Chowdary Deverapalli2, Bichchau Nguyen2
1Boston University School of Medicine, 72 E Concord St, Boston, MA, 02118, USA. sfazelpo@bu.edu.
Archives of dermatological research
|May 25, 2024
概括
皮肤有色 (SOC) 患者表现出不同的皮肤癌表现,与白人患者不同. 识别这些独特的特征有助于更早地诊断和更好地管理SOC个体的皮肤癌.
科学领域:
- 皮肤病学 皮肤病学
- 遗传学 遗传学 是一个
- 在瘤学瘤学.
背景情况:
- 基因皮肤病与增加皮肤癌风险有关.
- 目前的诊断指南和知识主要反映了白人患者的表现.
- 在了解皮肤色 (SOC) 种群中皮肤癌的表现方面存在显著差异.
研究的目的:
- 为了确定SOC患有基因皮肤病的患者皮肤发现的独特特征.
- 为了确定皮肤癌的位置,频率,严重程度和SOC个体发病年龄的变化.
- 改善基因皮肤病的SOC患者的诊断率和临床管理.
主要方法:
- 在六个数据库中对基因皮肤病的文献进行系统审查.
- 包括英语出版的病例报告和详细介绍成年SOC患者的系列.
- 提取病例级数据,包括人口统计,皮肤病特征和皮肤癌细节.
主要成果:
- 从381篇文章中对578名SOC患者的分析揭示了不同的表现.
- SOC患者可能表现出较少的经典发现,例如,戈林综合征的基底细胞癌发病率较低.
- 在SOC种群中观察到的变异,比如亚洲人与非洲人先天性硬症患者的白血病率更高.
- 皮肤癌发病的平均年龄因基因皮肤病变而异,从25岁 (罗斯蒙德-姆森综合征) 到53岁 (穆尔-托雷综合征).
结论:
- 在SOC患者中呈现出不同的皮肤和皮肤癌特征的基因皮肤病.
- 对这些特定表现的认识对于及时诊断至关重要.
- 早期诊断和干预可以减少SOC人群中与皮肤癌相关的发病率.
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