拉莫塞作为耐火性纤维肌痛的附加疗法:一个随机,双盲,安慰剂对照试验
Dong-Jin Park1, Hyemin Jeong1, Sung-Eun Choi1
1Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School & Hospital, Gwangju, Republic of Korea.
Rheumatology (Oxford, England)
|May 25, 2024
概括
静脉注射拉莫塞特朗可以为纤维肌痛患者提供短期的疼痛缓解,这些患者对标准治疗没有反应. 这项研究发现,它在减少疼痛强度和改善短期情绪方面是安全有效的.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
- 疼痛管理 疼痛管理
背景情况:
- 纤维肌痛 (FM) 是一种慢性疾病,其特点是普遍存在的疼痛和其他症状.
- 患有FM的患者往往对传统治疗有不充分的反应,需要探索替代治疗选择.
研究的目的:
- 评估静脉注射拉莫塞特朗在纤维肌痛患者的疼痛缓解中的疗效和安全性.
- 评估ramosetron对这种患者群体疼痛强度,抑郁和整体健康状况的影响.
主要方法:
- 一项前性,双盲,安慰剂对照试验,涉及80名 FM 患者.
- 患者接受了静脉注射拉莫塞 (0.3毫克/天5天) 或安慰剂.
- 疼痛强度使用视觉模拟量表 (VAS) 进行测量,并使用各种验证问卷评估二次结果.
主要成果:
- 在治疗结束时,与安慰剂相比,ramosetron组的VAS疼痛得分显著减少 (P <0.05).
- 在拉莫塞组中,贝克抑郁症清单 (BDI) 和多维健康评估问卷 (MDHAQ) 的得分也得到了显著改善.
- 这些好处在28天的随访中没有持续,最常见的不良事件是胃肠道,特别是便秘.
结论:
- 静脉注射拉莫塞特朗为纤维肌痛患者提供安全有效的短期疼痛缓解.
- 拉莫塞特朗可能是一个可行的选择,用于管理 FM 患者的疼痛,这些患者对标准疗法反应不佳.
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