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Updated: Jun 25, 2025

Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli
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非催化性聚烯基基因的突变破坏了TREX1的稳定,并放大了cGAS-STING信号传输

Abraham Shim1, Xiaohan Luan2, Wen Zhou2

  • 1Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 430 East 67th Street, New York, NY 10065, United States.

Human molecular genetics
|May 26, 2024
PubMed
概括

调节cGAS-STING通路的酶TREX1的突变可以导致自身免疫性疾病. 这项研究表明,TREX1聚烯螺旋基因的突变使蛋白质不稳定,导致免疫系统过度激活.

关键词:
艾卡迪-古蒂埃雷斯综合征是什么这就是TREX1的特点.cGAS-STING 的使用情况.具有天生的免疫力.聚二烯螺旋 (polyproline helix) 是一种聚二烯螺旋.

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