在糖尿病患者队列中,使用便弹性酶测试和PEI评分系统查未诊断的胰腺外分泌功能不足 (PEI)
V Parihar1,2, R Ballester3, P F Ridgway4
1Department of Gastroenterology, Tallaght University Hospital, TallaghtDublin 24, Ireland. Vikpar37@yahoo.com.
Acta diabetologica
|May 26, 2024
概括
一项研究发现,12%的糖尿病患者患有未诊断的胰腺外分泌功能不全 (PEI). 这突显了潜在的健康负担,因为PEI-S症状得分在这个群体中没有有效诊断PEI.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 1型和2型糖尿病 (DM) 经常与胰腺外分泌功能不全 (PEI) 相关.
- 糖尿病患者PEI的确切患病率和临床影响尚不清楚.
- 现有的研究表明PEI患病率的变化取决于诊断方法.
研究的目的:
- 通过便弹性酶-1 (FE-1) 试验,确定糖尿病队列中PEI的患病率.
- 为了验证患者报告的症状评分系统 (PEI-S) 对糖尿病患者的PEI诊断.
主要方法:
- 从大学医院诊所招募了233名糖尿病患者.
- 便弹性酶-1 (FE-1) 测定和PEI症状评分 (PEI-S) 用于诊断.
- PEI是由FE-1<200μg/g或PEI-S>0.6.6定义的
主要成果:
- 在166名返回便样本的患者中,12%的患者根据FE-1水平出现PEI.
- 在这种糖尿病人群中,吸烟被确定为PEI的危险因素.
- PEI-S系统没有有效地区分正常和低FE-1水平的糖尿病患者.
结论:
- 未诊断的PEI影响了1型和2型DM患者这一现实世界队列的12%.
- 2型DM的患病率上升表明PEI的重大,未被认可的负担具有潜在的长期健康后果.
- 在这种糖尿病患者群体中,PEI-S症状评分系统表现不佳.
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