短链脂肪酸和妊娠前:一个范围审查
Heather J Zhao1,2, Yingan Chen3,4, Tiange Liu1
1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, United States.
Nutrition reviews
|May 26, 2024
概括
短链脂肪酸 (SCFA),特别是酸盐,可能会防止孕前 (PE). 在PE患者中观察到较低水平的SCFA如丁酸盐和酸盐,这表明与疾病发展有联系.
科学领域:
- 产科和妇科 产科和妇科
- 胃肠病学 胃肠病学
- 代谢研究研究 代谢研究
背景情况:
- 孕前 (PE) 是一种严重的妊娠障碍.
- 肠道微生物群衍生的短链脂肪酸 (SCFA) 在PE中的作用尚不清楚.
研究的目的:
- 审查人类研究主要的SCFA (乙酸盐,酸盐,丁酸盐) 和PE在怀孕期间的发展之间的关联.
主要方法:
- 在EMBASE,PubMed,科学网络和Cochrane的系统文献搜索.
- 包括11项人类病例控制研究,共1318名参与者 (352名PE患者).
- 在怀孕期间收集的各种生物样本中分析了SCFA水平.
主要成果:
- 在7项研究中,在PE病例中,丁酸盐显著降低.
- 在PE病例中,乙酸盐水平主要较低,其中一项研究显示水平更高.
- 酸显示出混合的结果,一些研究报告了PE病例中的更高和更低水平.
结论:
- 来自病例控制研究的流行病学证据表明,SCFA,特别是酸盐,与PE的发展有关.
- 需要进一步的大型队列研究来确定时间性和因果关系.
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