第14天的血清C-反应蛋白值作为动脉瘤下arachnoid出血的可能预后因素
Fukutaro Ohgaki1, Junya Tatezuki1, Yasunori Takemoto1
1Department of Neurosurgery, Yokohama City Minato Red Cross Hospital, Yokohama, Kanagawa, Japan.
The Journal of international medical research
|May 26, 2024
概括
动脉瘤下关节出血 (aSAH) 后14天的血清C反应蛋白 (CRP) 水平表明患者的预后. 14日较低的CRP水平与更好的结果相关,表明有效的管理.
科学领域:
- 神经学 神经学
- 炎症标志物的炎症标志物
- 临床预后 临床预后
背景情况:
- 血清C-反应蛋白 (CRP) 反映了早期的脑损伤,并预测了动脉瘤下关节出血 (aSAH) 的预后.
- 一些严重的aSAH病例显示出尽管初始CRP水平很高,但预后良好,因此需要进一步调查CRP动态.
研究的目的:
- 调查aSAH急性阶段血清CRP转变与患者预后之间的关系.
- 为了确定急性阶段特定时间点的CRP水平是否与长期结果有关.
主要方法:
- 对63名aSAH患者的回顾性分析.
- 在aSAH后的1,3,14天检查血清CRP水平.
- 多重回归分析以评估CRP对预后的影响.
主要成果:
- 血清CRP水平在1,3,14天显著降低,与预后不佳的患者相比,预后良好的患者的血清CRP水平明显降低.
- 在多重回归分析中,1日和14日的血清CRP值是预后的显著预测指标.
结论:
- 14日低血清CRP值,与1日水平相比,与aSAH的良好预后有关.
- 到第14天,达到低血清CRP水平,表明受控的早期脑损伤和有效的管理,对于有利的aSAH结果至关重要.
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