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Updated: Jun 25, 2025

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
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在不耐药的青少年类风湿性疾病中使用JAK抑制剂:有效性,耐受性和I型干扰素分析,单一中心回顾性研究

Marie Solignac1, Natalia Cabrera2, Marine Fouillet-Desjonqueres3

  • 1Department of Pediatrics, Nantes University Hospital, Nantes, France; Department of Pediatric Rheumatology, Nephrology, and Dermatology, Lyon University Hospital, Lyon, France.

Journal of autoimmunity
|May 26, 2024
PubMed
概括

雅努斯激酶抑制剂 (JAKi) 通过减少干扰素刺激基因 (ISG) 来治疗儿科类风湿性疾病有希望. 虽然对一些人有效,但JAK抑制剂也会带来诸如体重增加等风险,需要进一步研究长期安全性.

关键词:
生物标志物生物标志物国际金融网络签名 IFN签名雅克抑制剂的使用儿童类类风湿性疾病安全的安全的安全的安全的安全.这是一种I型干扰子.体重增加 体重增加

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The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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