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大麻素受体2选择性激动剂通过JAK/SOCS3信号传递抑制Th2分化来缓解系统性硬化症

Na Tian1, Hao Cheng2, Yu Du3

  • 1Department of Rheumatology and Immunology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine of Ruijin Hospital, Department of Thoracic Surgery of Ruijin Hospital, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Journal of autoimmunity
|May 26, 2024
PubMed
概括

大麻素受体2 (CB2) 激动剂HU-308通过抑制Th2细胞两极化来降低系统性硬化 (SSc) 中的纤维化. 这种新的机制针对T细胞失衡,为SSc患者提供潜在的新疗法.

关键词:
大麻素受体2 类受体2肺部间歇性纤维化 肺部间歇性纤维化系统性硬化症 系统性硬化症Th2 反应反应的时间.

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