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抗菌素耐药性挑战的范围

Iruka N Okeke¹, Marlieke E A de Kraker², Thomas P Van Boeckel³

¹Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.

Lancet (London, England)

|May 26, 2024

概括

抗生素耐药性导致每年127万人死亡, 威胁全球健康和发展目标. 为了有效地衡量和打击这种日益增长的威胁,全面的监测至关重要.

科学领域:

全球健康
传染性疾病
公共卫生政策

背景情况:

每年有770万人死于细菌感染, 其中495万人死于耐药性病原体.
抗菌素耐药性 (AMR) 破坏了医学进步,阻碍了可持续发展目标,影响了新生儿的生存率和健康的衰老.
有效抗生素的可用性正在减少,特别是在资源有限的环境中,使弱势群体易受耐药性感染的影响.

研究的目的:

应对抗菌素耐药性 (AMR) 的全球挑战.
研究全球抗菌药物耐药性问题的范围.
确定有效的抗药性测量方法,以提供干预信息.

主要方法:

这篇论文是关于抗菌素耐药性的第一篇文章.
它回顾了AMR的全球范围和测量.
它强调需要强有力的,可操作的数据和全面的监测.

主要成果:

估计有127万人死于抗生素耐药的细菌病原体.
抗菌耐药性对实现全球卫生目标,包括新生儿存活率构成重大障碍.
易受感染的群体,包括年轻人,老年人和重病患者,

结论:

强有力的可操作数据对于推动变革和实施有效的抗抗药性干预措施至关重要.
监控系统必须在地理上全面,尽量减少基于医院的偏见,并包括非人类的存储库.
应对抗药物耐药性需要采用包括人类,动物和环境卫生部门在内的全球多方面的方法.

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