扩大抗生素,疫苗和诊断方法的开发和获取以应对抗菌素耐药性
Ramanan Laxminarayan1, Isabella Impalli2, Radha Rangarajan3
1One Health Trust, Bengaluru, India; High Meadows Environmental Institute, Princeton University, Princeton, NJ, USA.
Lancet (London, England)
|May 26, 2024
概括
全球抗生素耐药性感染的增加需要新的药物开发经济模式,重点是公共私营伙伴关系,以确保全球可负担的新型抗生素,疫苗和诊断方法.
科学领域:
- 抗菌药物耐药性
- 全球卫生经济学
- 制药创新
背景情况:
- 全球越来越多的细菌感染对现有抗生素有抗性, 这凸显了对新疗法的迫切需要.
- 传统的药物开发经济模式在没有激励措施的情况下是不可持续的,
- 有效的感染管理需要抗生素,疫苗和诊断的进步.
研究的目的:
- 探索抗生素研发的新经济模式.
- 确定确保负担得起和可持续获得新抗生素,疫苗和诊断方法的战略.
- 应对扩大诊断和促进感染预防的挑战.
主要方法:
- 分析传统抗生素研发模式的经济可行性.
- 检查药物开发的公私伙伴关系和公共资金机制.
- 对诊断缩放的技术,经济和行为挑战的审查.
- 评估疫苗在预防耐药性感染中的作用.
主要成果:
- 传统的研发模式在没有推动和拉动激励的情况下是经济不可行的.
- 公开资助的模式和公私伙伴关系可以降低成本并改善获取.
- 扩大诊断面临着重要的技术,经济和行为障碍.
- 对抗药物耐药性病原体的疫苗开发仍然缺乏资金.
结论:
- 重新思考研发对于疾病管理,预防和患者接入至关重要.
- 持续获得抗生素需要投资于新型替代品,诊断和感染预防策略.
- 公共资金和创新伙伴关系对于克服抗生素开发和获取经济障碍至关重要.
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